Previously Funded

Asthma                    
 Lung Cancer
COPD                    
 Other Lung Diseases

Asthma

Danit Ariel, MD
Stanford University Medical Center
Respiratory Health Association, The CHEST Foundation
The prevalence and severity of asthma is progressively increasing, and it is estimated that women account for 65% of deaths related to asthma. Recent research indicates that there is a relationship between obesity and asthma, and that insulin resistance may be the potential link. Dr. Ariel's research seeks to identify the role that insulin-resistance-directed therapy plays in achieving better asthma control, and explore associated gender differences.

Samuel Dorevitch, MD
University of Illinois at Chicago
Respiratory Health Association Research Grant
A dominant theory about the link between asthma and obesity focuses on inflammation (a component of both conditions) and an element of inflammation called oxidative stress. Dr. Dorevitch is investigating the relationship between asthma, obesity and oxidative stress within an urban African American community to gain more information about the link between asthma and obesity.

Ravi Kalhan, MD
Northwestern University
Respiratory Health Association Research Grant
Asthma is a complex disease that is determined by multiple genetic and environmental factors. Some research has noted a relationship between dietary intake of soy isoflavone and asthma severity. In particular, some research has shown that higher consumption of soy leads to decreased self report of cough and other respiratory symptoms. Dr. Kalhan is currently investigating whether dietary supplementation with soy will improve lung function, reduce symptoms and decrease airway inflammation.

Jerry Krishnan, MD
University of Chicago
American Thoracic Society/Respiratory Health Association Research Grant
Conventional treatment for a severe asthma attack includes using corticosteroids orally or intravenously, and the use of inhaled bronchodilators. These treatments, however, can take hours or days to provide benefits. Dr. Krishnan is examining the benefits of using high-doses of inhaled corticosteroids, in addition to conventional treatment, as a potential new therapy to improve outcomes of patients hospitalized for asthma.

Anne Marie Singh, MD
Northwestern University Feinberg School of Medicine
Respiratory Health Association, Blowitz-Ridgeway Foundation
Many children wheeze at a young age, but not all children who wheeze will develop asthma. Dr. Singh works with children who are too young to have been diagnosed or who have not yet received a positive diagnosis. For the study, she reviews the children's medical histories and takes a blood sample to find immune markers, allergic antibodies and other responses to triggers. She looks for commonalities among children who eventually develop asthma, such as similar immune responses or antibody levels.

COPD

Valerie Press, MD, MS
Assistant Professor, Hospitalist Scholar
The University of Chicago

Project: Video vss. TTG Respiratory inhaler technique Assessment and Instruction (V-TRAIN)
Funded by: Respiratory Health Association, American Thoracic Society Foundation, Emphysema Foundation for Our Right to Survive (EFFORTS)

Summary: Dr. Press is studying the effectiveness of a video-based strategy to teach hospitalized people living with COPD how to use their inhalers properly. This approach may improve patient management of their disease and reduce costs associated with hospitalization.

Kyle Hogarth, MD
University of Chicago
Catch Your Breath Research Award

Dr. Hogarth's research involves screening fluorescence bronchoscopy; a test that may improve early detection of pre-cancerous lesions in the large airways that are not detected by CT scan. Dr. Hogarth is looking at the clinical differences in men versus women for the detection of pre-cancerous lesions as well as the differences amongst women that develop lesions compared to those that do not.
Baxter Bioscience Educational Grant
Dr. Hogarth is designing a program to demonstrate that a direct-to-consumer education and awareness campaign can increase the number of COPD patients tested for alpha-1 antitrypsin deficiency (Alpha-1). Alpha-1 is an inherited disorder that can cause lung disease, such as chronic obstructive pulmonary disease (COPD).  

Sharon Rosenberg, MD
Northwestern University
Catch Your Breath Research Award
In 2000, for the first time, the number of women dying from chronic obstructive pulmonary disease (COPD) surpassed the number of men. Research has recently indicated that there are important differences in the presentation and course of COPD in men versus women. Dr. Rosenberg is researching COPD, including gender-based differences in co-morbid conditions (2 or more diseases that occur together) and gender-based differences in health status related to COPD.

Lung Cancer

Ravi Salgia, MD, PhD
Professor of Medicine, Pathology and Dermatology
Director, Chest Oncology and Thoracic Oncology Research Program
Vice Chair, Translational Research
The University of Chicago  

Funded by: Chicago Lung Run, Respiratory Health Association 
Summary: Dr. Salgia and his colleaguesat University of Chicago are studying features of lung cancer gene cells to determine variants and methods to detect those variants. The ultimate goal is to correlate responses to drug therapy. 

Jordi Tauler, PhD
Visiting Research Assistant Professor
University of Illinois at Chicago

Funded by: Chicago Lung Run, Respiratory Health Association 
Summary: Dr. Tauler is identifying mutations that drive cancer development and investigating the genes that these mutations affect, including myosin light chain kinase (MYLK), the pseudogene MYLKP1 and heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1). By studying cells found in lung tumors, he hopes to learn more about how cells mutate to form non-small cell lung cancer tumors. 

Navdeep Chandel, MD
Northwestern University
Lung Cancer Promise of Tomorrow Award*
Dr. Chandel's research involves adenocarcinoma, a type of non-small cell lung cancer that is increasingly affecting nonsmokers. Adenocarcinoma accounts for 30% of non-small cell lung cancer cases. Dr. Chandel is looking at a novel cellular signaling system that may lead to the development of adenocarcinoma. Understanding how this signaling system works in the cells may eventually lead to the development of new therapies to treat and prevent adenocarcinoma.

*Funded by LUNGevity Foundation, Arkansas Respiratory Health Association, Breathe California of the Bay Area, Breathe California of Los Angeles County, Breathe New Hampshire, and Respiratory Health Association

Ravi Salgia, MD, PhD
University of Chicago
Funded through proceeds from the Chicago Lung Run
Adenocarcinoma is a type of non-small cell lung cancer, and is the most common type of lung cancer in nonsmokers. Dr. Salgia's research involves studying the biomarkers in tumor and blood of women who smoke and women who don't smoke with adenocarcinoma. This highly innovative research will provide insight into developing a blood test for adenocarcinoma in women, as well as provide some insight into the genes that may involved.

Other Lung Diseases

Lt. Angela DiCarlo-Meacham, MC, USN, MD
US Naval Hospital 

Project: Exercise During pregnancy and prevention of dyspnea of pregnancy
Funded by: The CHEST Foundatioin, Respiratory Health Association 

Summary: Lt. Angela Di-Carlo-Meacham, MC, USN, MD, U.S. Naval Hospital, Okinawa, Obstetrics and Gynecology, is investigating exercise and dyspnea during pregnancy. Approximately 70 percent of women experience dyspnea, which is difficulty breating during pregnancy. Often, this uncomfortable feeling is a normal body response to pregnancy. The goal of the study is to evaluate the effect of regular aerobic exercise throughout pregnancy on the development of dyspnea of pregnancy.

Blanca Camoretti-Mercado, PhD
University of Chicago
Catch Your Breath Research Award
Dr. Camoretti-Mercado is researching LAM (lymphangioleiomyomatosis), a rare lung disease that mostly affects women in their 30s and 40s. In particular, Dr. Camoretti-Mercado is looking into the molecular mechanisms involved with the development of LAM. Increased understanding may lead to new and effective therapies for LAM.

Tuberculosis Epidemiologic Studies Consortium
A number of tuberculosis research projects are underway through a 10-year contract with the Centers for Disease Control and Prevention (CDC). This research, conducted through the CDC's Tuberculosis Epidemiologic Studies Consortium, and in collaboration with the Metropolitan Chicago Tuberculosis Coalition works to strengthen, focus and coordinate tuberculosis research.